Chikhulupiliro Ng'ombe was diagnosed with Acute Lymphoblastic Leukaemia in 1992, at the age of eight. After three years of chemotherapy and radiotherapy, he was declared cancer-free.

While studying his degree in HIV/AIDS management in 2011, he was compelled to establish a non-profit organisation, Cancer Survivors Quest, that would act as a platform for cancer survivors to develop plans to support other cancer patients and survivors through psychosocial care. Chikhulupiliro is the Executive Director and coordinates most of the programmes at Cancers Survivors Quest. With limited financial support, the organisation is sustained through crowdsourcing, social entrepreneurship and practical budgeting.

Over time, he has assisted in the establishment of the NCD Alliance Malawi and has also supported in the fight against epilepsy through Epilepsy Warriors Foundation as the Project Manager. He has worked closely with the NCD Alliance’s Our Views, Our Voices initiative as a Global Advisory Committee member. In 2025, Chikhulupiliro joined the NCD Alliance Board (2025-2027) as the Lived Experience Board Member. He has spent significant time advocating on NCD issues with local governments, both through formal advisory roles and personal advocacy.

In his current position on the NCD Alliance Board, he brings lived experience perspectives into global advocacy spaces. This role enables him to influence international dialogue, strengthen the connection between communities and decision-makers, and contribute to more inclusive, person-centred approaches to health policy and systems change, something he is passionate about.

Chikhulupiliro is associated with Malawi NCD Alliance and Cancer Survivors Quest.